Interleukin 2 induced cytotoxicity on renal cell carcinoma. 2 Synergistic effects of interleukin 2 and interferon gamma.

نویسندگان

چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Interleukin 2 induced cytotoxicity on renal cell carcinoma. 2. Synergistic effects of interleukin 2 and interferon gamma.

In the previous paper, it was shown that interleukin 2 (IL-2) enhanced NK cell activity against renal carcinoma cell lines and fresh solid tumor cells of renal cell carcinoma (RCC) which are not susceptible to NK cells, and that IL-2 in duced a higher cytotoxicity than interferon ƒÁ (IFN-ƒÁ). The present study was carried out to examine the mechanism of the en hanced cytotoxicity of IL-2 and IF...

متن کامل

Effects of stimulating interleukin -2/anti- interleukin -2 antibody complexes on renal cell carcinoma

BACKGROUND Current therapies for advanced renal cell carcinoma (RCC) have low cure rates or significant side effects. It has been reported that complexes composed of interleukin (IL)-2 and stimulating anti-IL-2 antibody (IL-2C) suppress malignant melanoma growth. We investigated whether it could have similar effects on RCC. METHODS A syngeneic RCC model was established by subcutaneously injec...

متن کامل

Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells

Gamma interferon induced surface expression of interleukin 2 (IL-2) receptors on normal human monocytes and the monocytoid cell lines U937 and HL60. These receptors were detected by anti-IL-2 receptor monoclonal antibodies, and U937 IL-2 receptors were indistinguishable from T lymphocyte IL-2 receptors by immunoprecipitation. Also, U937 IL-2 receptors bound biologically active IL-2. These resul...

متن کامل

Effects of dexamethasone on human natural killer cell cytotoxicity, interferon production, and interleukin-2 receptor expression induced by microbial antigens.

Dexamethasone inhibits the expression of the interleukin-2 receptor, the synthesis of immune interferon, and the development of natural killer cells when added to peripheral blood mononuclear cells cultured with soluble microbial antigens (purified protein derivative and a polysaccharide extract from Candida albicans [MPPS]) or human recombinant interleukin-2.

متن کامل

Effect of Vitamin D treatment on Interleukin-2 and Interleukin-4 Genes expression in Multiple Sclerosis

Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The Keio Journal of Medicine

سال: 1986

ISSN: 1880-1293,0022-9717

DOI: 10.2302/kjm.35.90